Sex Hormones and Inflammatory Biomarkers in Patients With Sickle Cell Disease

Completed

Conditions studied: Sickle Cell Disease, Vaso-occlusive Crisis

In brief

This study aims to characterize sex differences in the pathophysiology of vaso-occlusive crises (VOC) occurring among individuals with sickle cell disease (SCD). * The study will compare CRP and other biomarkers between females with SCD in the follicular phase of the menstrual cycle and males with SCD. * The study will explore potential sex differences in biomarker changes between females and males with SCD during and following resolution of VOC. * The study will compare neutrophil and platelet adhesion to the endothelium and real time fibrin deposition in the blood.

Key facts

Study ID

NCT06345638

Run by

University of Pennsylvania

People needed

52

Starts

2024-03-01

Expected to finish

2025-06-17

Last updated by the study team

2025-08-05

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult males and females aged 18-45
• Diagnosis of sickle cell disease
• current hospitalization for vaso-occlusive pain episode or current outpatient infusion at the recruiting sites
• Able to read and understand English
• Willing to comply with study procedures

You may not qualify if…

• Currently pregnant, pregnant within the last month, or seeking to become pregnant

Where it is running

• Penn Medicine University City — Philadelphia, Pennsylvania, United States
• Pennsylvania Hospital — Philadelphia, Pennsylvania, United States
• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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