Detecting Mild Autonomous Cortisol Secretion in Patients With Adrenal Incidentaloma

Recruiting now

Conditions studied: Mild Autonomous Cortisol Secretion (MACS)

In brief

The aim of the proposed study is to estimate the incidence of Mild Autonomous Cortisol Secretion (MACS) in patients with Adrenal Incidentaloma (AI) and evaluate the available diagnostic tests to determine the most sensitive and specific combination of tests for assessing MACS from adrenal adenoma for prediction of the phenotype associated with cortisol excess. As well as following the patients for 4 years and see if anything changes.

Key facts

Study ID

NCT06344143

Run by

The Cleveland Clinic

People needed

20

Starts

2024-11-20

Expected to finish

2030-12-31

Last updated by the study team

2026-01-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients ages 18 years and older.
• Presence of adrenal incidentaloma by cat scan (CT) or magnetic resonance imaging (MRI) examination.
• 1-mg Dexamethasone suppression test cortisol ≤ 5 μg/dL with adequate dexamethasone level.

You may not qualify if…

• 1-mg Dexamethasone suppression test cortisol > 5 μg/dL with adequate dexamethasone level. Patients who fail to suppress below this level will be considered to have Cushing's syndrome and will be referred for appropriate treatment.
• Current or recent (3 months) history of use of glucocorticoid medication (including joint injections of steroids).
• History of uncontrolled hypertension or history of hypertension with more than 2 medications.
• History of uncontrolled type 2 Diabetes Mellitus or history of diabetes mellitus with A1c>7.5.
• Known History of osteoporosis
• Documented Clinical Cushing's disease.
• Clinical suspicion of adrenal carcinoma.
• History of alcohol abuse/dependence.
• History of cirrhosis of liver.
• History of hepatitis B or C infection regardless of treatment.
• History of type 1 diabetes.
• History of hemochromatosis.
• History of autoimmune hepatitis.
• History of Wilson's disease.

Where it is running

• The Cleveland Clinic Foundation — Cleveland, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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