An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer
Recruiting now
Conditions studied: Hepatocellular Carcinoma, Intrahepatic Cholangiocarcinoma, Cholangiocarcinoma, Primary Liver Cancer, Primary Liver Carcinoma, Hepatic Cancer, Hepatic Carcinoma
In brief
It is sometimes difficult to precisely understand whether a primary liver cancer is a hepatocellular carcinoma or a cholangiocarcinoma. The researchers will develop and validate a liquid biopsy, based on exosomal content analysis and powered by machine learning, to help clinicians differentiate these two cancers before surgery.
Key facts
- Study ID
- NCT06342414
- Run by
- City of Hope Medical Center
- People needed
- 400
- Starts
- 2024-03-15
- Expected to finish
- 2028-06-18
- Last updated by the study team
- 2026-07-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- A histologically confirmed diagnosis of hepatocellular carcinoma
- A histologically confirmed diagnosis of intrahepatic cholangiocarcinoma
- Received standard diagnostic and staging procedures as per local guidelines
- Availability of at least one blood-derived sample, drawn before receiving any curative-intent treatment
You may not qualify if…
- Lack of or inability to provide informed consent
- Synchronous hepatocellular carcinoma and intrahepatic cholangiocarcinoma
- Primary liver cancer other than hepatocellular carcinoma or intrahepatic cholangiocarcinoma
- Secondary liver cancer
Where it is running
- City of Hope Medical Center — Duarte, California, United States (enrolling)
- Graduate School of Medical Sciences, Kyushu University — Fukuoka, Japan (enrolling)
- Graduate School of Medical Sciences, Kumamoto University — Kumamoto, Japan (enrolling)
- Hokkaido University Graduate School of Medicine — Sapporo, Japan (enrolling)
- Tokushima University — Tokushima, Japan (enrolling)
Full record on ClinicalTrials.gov
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