Early Onset Colorectal Cancer Detection

Recruiting now

Conditions studied: Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenocarcinoma, Colorectal Cancer Stage I, Colorectal Cancer Stage IV, Colorectal Cancer Stage II, Colorectal Cancer Stage III, Colorectal Neoplasms Malignant

In brief

Colorectal cancer (CRC) once predominantly affected older individuals, but in recent years has witnessed a progressive increase in incidence among young adults. Once rare, early-onset colorectal cancer (EOCRC, that is, a CRC diagnosed before the age of 50) now constitutes 10-15% of all newly diagnosed CRC cases and it stands as the first cause of cancer-related death in young men and the second for young women. This study aims to detect EOCRC with a non-invasive test, using a blood-based molecular assay based on microRNA (ribonucleic acid)

Key facts

Study ID

NCT06342401

Run by

City of Hope Medical Center

People needed

400

Starts

2023-04-15

Expected to finish

2028-06-18

Last updated by the study team

2026-07-07

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Stage I, II, III, IV colorectal cancer (TNM classification, 8th edition) diagnosed before the age of 50 (EOCRC cases)
• Received standard diagnostic and staging procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment
• Colonoscopy-proven cancer-free status at the time of study inclusion (Non-disease controls)

You may not qualify if…

• Hereditary colorectal cancer syndromes (identified through genetic testing)
• Inflammatory bowel diseases
• Lack of written informed consent

Where it is running

• City of Hope Medical Center — Duarte, California, United States (enrolling)
• IRCCS San Raffaele — Milan, Italy (enrolling)
• Kawasaki University — Kawasaki, Japan (enrolling)
• Mie University — Mie, Japan (enrolling)
• National Cancer Center Hospital — Tokyo, Japan (enrolling)
• Tokyo Medical and Dental University — Tokyo, Japan (enrolling)
• Yamagata University — Yamagata, Japan (enrolling)
• Barcelona University — Barcelona, Spain (enrolling)
• Colorectal Surgery, Vall d'Hebron University Hospital, Universitat Autonoma de Barcelona UAB — Barcelona, Spain (enrolling)
• Surgery Department, Hospital del Mar, Barcelona, Spain — Barcelona, Spain (enrolling)
• Salamanca Biomedical Research Institute — Madrid, Spain (enrolling)
• University of Salamanca-SACYL-CSIC, Salamanca, Spain — Salamanca, Spain (enrolling)
• University of La Laguna — San Cristóbal de La Laguna, Spain (enrolling)

Full record on ClinicalTrials.gov

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