Assessment of Volume-targeted Ventilation in Patients With Neuromuscular Disease

Recruiting now · Phase 2

Conditions studied: Neuromuscular Diseases

In brief

Assessment of safety and efficacy of volume-targeted ventilation in patients with neuromuscular disease.

Key facts

Study ID

NCT06339580

Run by

Guy's and St Thomas' NHS Foundation Trust

People needed

30

Starts

2024-04-09

Expected to finish

2026-09-30

Last updated by the study team

2026-06-08

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Slowly progressive neuromuscular disease
• Established on fixed bi-level ventilation
• Documented clinical respiratory stability by supervising clinician (no hospitalizations, respiratory infections or change to ventilator settings in preceding 6 weeks)

You may not qualify if…

• Rapidly progressive neuromuscular disease
• Decompensated respiratory failure (pH < 7.35)
• Pregnancy
• Aged <18, >80
• Poor adherence to NIV (<4hrs per night)
• Significant physical or psychiatric co-morbidity that would prevent compliance with trial protocol

Where it is running

• Guy's & St Thomas' NHS Foundation Trust — London, London, United Kingdom (enrolling)
• Guy's and St. Thomas NHS Foundation Trust — London, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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