Repurposing Lithium for Parkinson's Disease: a RCT
Running, not enrolling · Phase 1/Phase 2 · Has a placebo group
Conditions studied: Parkinson Disease
In brief
This study will examine the effects of lithium 20mg/day compared to placebo on MRI and blood-based biomarkers among 20 early-stage Parkinson's disease patients.
Key facts
- Study ID
- NCT06339034
- Run by
- State University of New York at Buffalo
- People needed
- 20
- Starts
- 2024-07-03
- Expected to finish
- 2026-09-01
- Last updated by the study team
- 2026-06-16
Who can join
Age: 40 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Have PD for <4 years diagnosed by a movement disorder specialist. Have normal thyroid and renal function at the screening visit. Have no previous exposure to lithium therapy. Have no history of brain surgery. Have no hx of brain imaging findings suggesting another neurological condition besides PD.
- Have no use of tobacco or THC products for >1 year. Have stable PD medications for >30 days without current need for adjustments in the investigator's opinion.
- Have stable psychiatric and diuretic medications for >60 days with no anticipated need for changes for at least 24 weeks.
- Have no active medical or psychiatric condition that may interfere with study procedures in the investigator's opinion.
You may not qualify if…
- Have PD for >4 years or does not have PD. Have abnormal normal thyroid and renal function at the screening visit. Have previous exposure to lithium therapy. Have history of brain surgery. Have hx of brain imaging findings suggesting another neurological condition besides PD.
- Have use of tobacco or THC products within the past year. Have PD medication adjustments within 30 days or needs PD medication adjustments in the investigator's opinion.
- Have psychiatric or diuretic medication adjustments within the last 60 days or is anticipated to need changes over next 24 weeks.
- Have active medical or psychiatric condition that may interfere with study procedures in the investigator's opinion.
Where it is running
- UBMD Neurology — Williamsville, New York, United States
Full record on ClinicalTrials.gov
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