Potential Role of Sirtuins As Epigenetic Biomarkers of the Patient with Atherosclerosis or Calcific Aortic Stenosis

Recruiting now

Conditions studied: Atherosclerosis and Calcific Aortic Stenosis with and Without Diabetes

In brief

The project aims to shed light on the role of Sirtuins, enzymes belonging to the third class of histone deacetylases (class III) involved in epigenetic modifications (deacetylation), focusing mainly on Sirtuin 6 (SIRT6), as a regulator of atherosclerosis and severe aortic valve stenosis through molecular-based and epigenetic studies in human VSMC cells.

Key facts

Study ID

NCT06337227

Run by

IRCCS SYNLAB SDN

People needed

3

Starts

2023-10-19

Expected to finish

2026-10-01

Last updated by the study team

2025-03-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients with atherosclerosis or calcific aortic stenosis with and without diabetes older than 18 years of either sex;
• Patients without atherosclerosis undergoing surgical procedure for endocarditis;
• Patients who will have signed informed consent

You may not qualify if…

• Patients for whom biological material cannot be recovered for study purposes;
• Patients who refuse to participate in the study

Where it is running

• Irccs Synlab Sdn — Naples, Italy (enrolling)

Full record on ClinicalTrials.gov

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