Inspiratory Muscle Training on The Severity of Exercise-Induced Bronchoconstriction and Time-Trial Performance (IMT_EIB)

Completed · Not applicable · Has a placebo group

Conditions studied: Exercise Induced Bronchospasm, Exercise Induced Asthma

In brief

Due to the lack of studies examining the impact of inspiratory muscle training (IMT) on the severity of exercise-induced bronchoconstriction (EIB) and exercise performance, the specific aim of this study is to assess the efficacy of flow-resistive IMT on EIB severity and symptoms, short-acting beta-2-agonist medication use, operating lung volumes, respiratory and limb locomotor muscle deoxygenation during constant-load cycling exercise, exertional dyspnea, and cycling time-trial performance.

Key facts

Study ID

NCT06336681

Run by

Indiana University

People needed

15

Starts

2022-02-10

Expected to finish

2025-04-30

Last updated by the study team

2026-05-12

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male and female, between the ages of 18 to 35 years.
• Required to be a competitive recreational or college athlete and have at least 1-2 years of cycling or biking experience.
• Body Mass Index (BMI) of 18.5 to 28 kg/m\^2
• Considered "moderately to highly active" by the International Physical Activity Questionnaire (IPAQ).
• Have clinically treated mild to moderate persistent asthma and/or exercise-induced bronchoconstriction (EIB), with a resting forced expiratory volume in 1 second (FEV1) > 65% of predicted.
• A ≥ 10% drop in FEV1 after eucapnic voluntary hyperpnea (EVH).
• Prescribed short-acting β2-agonists (SABAs) by a physician.
• Comfortable not taking SABA before experimental visits.

You may not qualify if…

• History of smoking or recreational smoking, cardiovascular disease, renal disease, neurological disease, and metabolic disease.
• Currently taking asthma maintenance medications (e.g., corticosteroids and leukotriene modifiers)
• Any injuries in the past 6 months.
• Taking selective serotonin reuptake inhibitors (SSRI)'s (antidepressants and anxiety medication), attention-deficit hyperactivity disorder (ADHD) medication, and chronically consume pain medication (Aleve, Tylenol, cannabidiol (CBD), etc.).
• Has had or is positive for COVID-19.
• Resting blood pressure of > 130 mmHg systolic or 90 mmHg diastolic.
• Resting Pulse rate of > 100 bpm.
• Regularly consuming fish oil supplements or eating more then one fish meal per week

Where it is running

• School of Public Health-Bloomington — Bloomington, Indiana, United States

Full record on ClinicalTrials.gov

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