Structured Personalized Oxygen and Supportive Therapies for Dyspnea in Oncology

Recruiting now · Phase 2

Conditions studied: Dyspnea

In brief

To learn about the effect of Structured Personalized Oxygen and Supportive Therapies for Dyspnea in Oncology (SPOT-ON) treatment on the severity of shortness of breath in patients with cancer.

Key facts

Study ID

NCT06336642

Run by

M.D. Anderson Cancer Center

People needed

150

Starts

2024-06-11

Expected to finish

2032-03-31

Last updated by the study team

2026-08-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of cancer
• Age 18 or older.
• Admitted to a medical floor.
• Dyspnea intensity at rest of at least 4 on a 0-10-point NRS (where 0 = none, 10 = worst).
• Speak English or Spanish.

You may not qualify if…

• Hemodynamic instability requiring active Merit Team or ICU team involvement.
• Delirium as per clinical team's assessment in the Electronic Health Record (EHR).
• Severe hypoxemia (SpO2 < 90% despite supplemental oxygen of up to 6 L/min).
• Continuous positive airway pressure (CPAP) use for obstructive sleep apnea, actively using >10 hours a day.
• Respiratory failure necessitating mechanical ventilation (i.e., HFNC or NIV), and planned thoracentesis within 72 hours of enrollment.
• Patients with known pregnancy.

Where it is running

• MD Anderson Cancer Center — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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