ALIGN: Aligning Medications With What Matters Most (Demonstration)
Completed · Not applicable
Conditions studied: Polypharmacy, Alzheimer's Disease and Related Dementias, Mild Cognitive Impairment
In brief
The goal of this clinical trial is to test the effectiveness of a pharmacist-led, primary care-based de-prescribing intervention for people living with dementia (PLWD) and the person's care partners. The intervention consists of the following strategies: 1) a de-prescribing educational brochure designed to activate the patient and care partner; 2) a single telehealth visit in which an embedded clinical pharmacist discusses the benefits and harms of the patient's medications with the patient and care partner in the context of the person's goals and preferences; and 3) pharmacist-PCP communication in which the pharmacist provides tailored de-prescribing recommendations designed to be useful and actionable for the PCP. The investigators will compare the intervention group with the waitlist control group to see if there is a difference in the primary outcome, the proportion of patients who deprescribe at least one medication by 3 months.
Key facts
- Study ID
- NCT06335953
- Run by
- Johns Hopkins University
- People needed
- 474
- Starts
- 2024-05-07
- Expected to finish
- 2025-10-18
- Last updated by the study team
- 2026-08-06
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age ≥65 years
- Diagnosis of dementia from International Classification of Diseases (ICD-10) visit codes or from the EHR problem list
- Five or more medications
- Only active patients, defined as having >1 visit to the primary care clinic within the past year will be included
- Care partners:
- Family or other companions >21 years old who regularly help the patient manage medications.
You may not qualify if…
- As the pragmatic trial will be based on primary care, individuals residing in long-term care facilities or enrolled in hospice will be excluded.
- Participants must hear well enough to communicate by telephone in English.
Where it is running
- Johns Hopkins Community Physicians — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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