Prophylactic Properties of Carrot Juice in Patients With High-Risk Colorectal Polyps
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Colorectal Cancer Prevention
In brief
The goal of this prospective randomized double-blinded bi-national study is to test the prophylactic effect of polyacetylenes from carrots on the population of patients who had a resection of high-risk adenomas of the large bowel. The main question it aims to answer is: Will carrot juice rich in polyacetylenes inhibit neoplastic transformation and growth in high-risk humans? Participants will have to drink 100 ml of juice daily after the adenoma resection for 1 year and keep a simple diary/calendar. Researchers will compare the group with ingestion of Falcarinol (FaOH) / Falcarindiol (FaDOH) rich carrot juice versus the group consuming placebo juice, to see if the polyacetylenes significantly reduces neoplastic transformation and growth in high-risk patients.
Key facts
- Study ID
- NCT06335420
- Run by
- Odense University Hospital
- People needed
- 400
- Starts
- 2024-06-20
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2025-11-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Any type of resection for adenomas larger than 20 mm in size (endoscopically evaluated) or endoscopically resected T1 cancers.
- Acceptance of the treatment and follow-up program.
- Capability to understand and follow the instructions.
You may not qualify if…
- Patients allocated to "high-risk" group because of many small polyps (>4).
- Pregnancy.
- Known relevant allergies.
- Chronic consumption of COX (cyclooxygenase) inhibitors (Aspirin, Celecoxib, Ibuprofen, Diclofenac, Ketoprofen, Ketorolac, Indometacin, Naproxen, Piroxicam) or immunosuppressive agents (Methotrexate, Azathioprine or glucocorticoids).
- Patients with different neoplastic disease under treatment (Chemo-/Radio-/Imunotherapy).
- Severe comorbidity NYHA III-IV.
- Lynch syndrome.
Where it is running
- Department of Surgery, Odense University Hospital — Odense, Denmark (enrolling)
Full record on ClinicalTrials.gov
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