Molecular Signatures Associated With Response to ICS Treatment in Patients With COPD Stratified by Eosinophil Levels
Recruiting now · Phase 4
Conditions studied: Chronic Obstructive Pulmonary Disease
In brief
The 3TR-ICS COPD study is an international, multicentre, randomized, parallel, controlled study that will recruit clinically stable former smokers COPD patients (with no exacerbations in the previous 8 weeks) on treatment with dual long-acting bronchodilators (LABA+LAMA), minimum 8 weeks of usage, not receiving ICS (either naïve or \> 3 months since last usage). The overall objective of this clinical trial is to identify the molecular signatures associated with the molecular response to ICS treatment in patients with COPD stratified by the levels of circulating eosinophils, and the potential influence of the pulmonary microbiome
Key facts
- Study ID
- NCT06334575
- Run by
- Maria Joyera Rodríguez
- People needed
- 135
- Starts
- 2025-02-12
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-07-20
Who can join
Age: 40 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male and female patients ≥40 years of age.
- ≥ 10 pack-years smoking.
- Former smokers (≥6 months).
- post-bronchodilator FEV1/FVC<0.70.
- FEV1 ≥30 (i.e. mild-moderated COPD patients).
- Signed written informed consent form.
- On regular treatment with dual long-acting bronchodilators (LABA+LAMA), minimum 8 weeks of usage.
- Women of child-bearing potential* must have a negative pregnancy test in serum or urine before the inclusion in the study and agree to use highly effective contraceptive methods during the study. Highly effective contraceptive methods will include: intrauterine device, bilateral tubal occlusion, vasectomized partner and sexual abstinence.
- Hormonal contraceptive methods will be avoided due to the risk of adverse events and impairment of liver function.
You may not qualify if…
- Presence of other respiratory disorders, (i.e. current physician diagnosis of asthma, early life history of asthma (<21 years) a previous clinical diagnosis of bronchiectasis, interstitial lung disease, pulmonary eosinophilia).
- Long-term oxygen therapy or non-invasive mechanical ventilation at home.
- Current smokers.
- Active cancer.
- Use of ICS in the 3 months prior to the recruitment.
- Participating in another randomized trial.
- Not likely to complete the study.
- Pregnant or breastfeeding females.
- Exacerbations in the previous 8 weeks.
- Primary or secondary immunodeficiency.
- Immunosuppression or regular oral corticosteroid treatment.
- Allergy to IMP's excipients.
- Any circumstances which could contradict study participation and lead the investigator to assess the patient as unsuitable for study participation for any other reason.
Where it is running
- Philips University of Marburg — Marburg, Germany (enrolling)
- Academisch Ziekenhuis Groningen — Groningen, Netherlands (enrolling)
- Clínic Barcelona — Barcelona, Spain (enrolling)
- Son Espases — Palma de Mallorca, Spain (enrolling)
- University of Leicester — Leicester, United Kingdom
- Imperial College London — London, United Kingdom
Full record on ClinicalTrials.gov
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