Cardiometabolic Function in Offspring, Mother and Placenta After Assisted Reproductive Technology
Recruiting now
Conditions studied: ART, IVF, Children, Only, Cardiovascular Disease Other
In brief
The overall objective is to establish the first-of-its-kind longitudinal cohort of pregnant women, biological fathers/partners and offspring from pregnancies achieved by frozen embryo transfer (FET), fresh-embryo transfer (fresh ET) and naturally conceived (NC) to investigate maternal cardiometabolic profiles, fetal growth patterns and placental function during pregnancy as well as metabolic and endocrine health in the offspring. Additionally, the aim is to explore genetic and epigenetic patterns in placenta, fetus and parents. As secondary objectives, the investigator group will examine telomere length and minipuberty hormones in children born after FET, fresh-ET and NC.
Key facts
- Study ID
- NCT06334003
- Run by
- Rigshospitalet, Denmark
- People needed
- 600
- Starts
- 2024-05-17
- Expected to finish
- 2027-01-01
- Last updated by the study team
- 2024-11-25
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Pregnant women who have either had fertility treatment at Rigshospitalet or Herlev Hospital (FET and fresh ET groups) or are scheduled for prenatal ultrasounds at Rigshospitalet or Herlev Hospital (NC group) will be screened for eligibility. Inclusion must happen before their routine ultrasound scan in 1. trimester.
You may not qualify if…
- Maternal pregestational diabetes type 1 or 2
- Non-singleton pregnancies
- Maternal pregestational BMI > 35 kg/m2
- Severe maternal co-morbidity
- Oocyte donation
Where it is running
- Fertility Clinic, Rigshospitalet, Copenhagen University Hospital — Copenhagen, Denmark (enrolling)
- Department of Fetalmedicin, Herlev Hospital — Copenhagen, Denmark (enrolling)
- Dept. of Paediatric and Adolescent Medicine, Herlev Hospital — Copenhagen, Denmark
Full record on ClinicalTrials.gov
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