Radiation Therapy for Dupuytren's Contracture Following Non-Surgical Release

Recruiting now · Not applicable

Conditions studied: Dupuytren Contracture

In brief

The goal of this study is to learn about preventing recurrence of Dupuytren's Contracture. The main question it aims to answer are: • Does targeted radiation therapy decrease recurrence of Dupuytren's contracture after treatment with Collagenase Clostridium Histolyticum? Participants will undergo: * Release of Dupuytren's Contracture after Collagenase Clostridium Histolyticum injection * Daily radiation therapy treatment for 5 days followed by 6-8 week rest period and then another course of 5 days of radiation therapy

Key facts

Study ID: NCT06330545
Run by: Dartmouth-Hitchcock Medical Center
People needed: 95
Starts: 2024-09-16
Expected to finish: 2032-04-01
Last updated by the study team: 2026-07-28

Who can join

Age: 45 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Age 45 or greater with DC
Extension deficit >10 degrees
Unable to simultaneously place the affected finger and palm flat on a table.
Women included in the study will be post-menopausal or using contraception, and a pregnancy test will be performed as standard of care.
For patients who are having multiple CCH injections, only the first 2 joints on given hand will be included

You may not qualify if…

Unsuccessful non-surgical release (> N/1 disease)
They develop an open wound during CCH
Breast feeding or pregnancy
A chronic muscular, neurologic, or neuromuscular disorder affecting the hands.
Less than the age of 45
They have previously undergone radiation on the hand in which they plan to get CCH injections
They are pregnant women, impaired adults or prisoners

Where it is running

Dartmouth Hitchcock — Lebanon, New Hampshire, United States (enrolling)

Full record on ClinicalTrials.gov

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