Genetics in Parkinson's Disease: Behavioral and Cognitive Outcomes

Recruiting now

Conditions studied: Parkinson Disease

In brief

The genetic landscape of Parkinson's disease (PD) is characterised by rare high penetrance pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a significant minority in PD cases and high frequency, low penetrance variants, which contribute a small increase of the risk of developing sporadic PD. This knowledge has the potential to have a major impact in the clinical care of people with PD. The goal of this observational study is to evaluate the impact of genetic mutation on behavior and cognition in PD patients. Patients will be assessed over time using test, questionnaire and standardised clinica scales. An initial assessment and annual follow-up assessments will be carried out for 5 years. Researchers will compare data collected from patients with genetic mutation versus patients without mutation.

Key facts

Study ID

NCT06329739

Run by

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

People needed

68

Starts

2021-12-14

Expected to finish

2031-12-14

Last updated by the study team

2024-03-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• diagnosed with Parkinson's Disease (PD)
• in use of dopaminergic medication (L-Dopa and/or dopamine agonists)
• genetic testing for mendelian forms of PD
• able to provide informed consent to participate in the study

You may not qualify if…

• Patients underwent Deep Brain Stimulation (DBS) treatment

Where it is running

• Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico — Milan, Italy (enrolling)

Full record on ClinicalTrials.gov

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