Establishing Pressures at the EGJ During Diaphragmatic Breathing Using High-resolution Esophageal Manometry

Completed · Not applicable

Conditions studied: Gastroesophageal Reflux, Dysphagia, Esophageal Motility Disorders

In brief

The goal of this study is to determine which position, maneuvers or combination thereof generates the highest pressure at the EGJ as assessed by high-resolution esophageal manometry and thus greater or more robust contraction of the diaphragm.

Key facts

Study ID

NCT06329583

Run by

Mayo Clinic

People needed

13

Starts

2024-05-10

Expected to finish

2026-04-02

Last updated by the study team

2026-04-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• patients undergoing high-resolution esophageal manometry

You may not qualify if…

• prior esophageal or gastric surgery
• chest tube
• major concomitant illness
• sinus disease precluding manometry placement
• history of heavy alcohol or tobacco use
• poor comprehension and/or fluency of English language
• inability or unwillingness of individual to give written informed consent

Where it is running

• Mayo Clinic — Jacksonville, Florida, United States

Full record on ClinicalTrials.gov

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