Comparing Efficiency of Mirogabalin and Pregabalin in Primary TKA

Recruiting now · Not applicable

Conditions studied: Pain Postoperative, Osteoarthritis, Total Knee Arthroplasty

In brief

The goal of this RCT is to compare efficacy between mirogabalin and pregabalin in pain reducing after unilateral primary total knee arthroplasty. The main question\[s\] it aims to answer are: • Does mirogabalin have better pain reduction than pregabalin after unilateral primary total knee arthroplasty. Participants will randomized to mirogabalin or pregabalin group and will take the drug for 2 weeks after TKA. Researchers will compare to pregabalin group to see pain and functional outcomes after TKA.

Key facts

Study ID

NCT06328062

Run by

Thammasat University Hospital

People needed

80

Starts

2024-04-01

Expected to finish

2026-08-31

Last updated by the study team

2026-08-07

Who can join

Age: 50 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 50-85 years old
• Unilateral primary osteoarthritis undergoing primary TKA
• ASA I-III

You may not qualify if…

• GFR \<60
• Allergy to drug in this study
• Cannot underwent spinal anesthesia and adductor canal block
• Taking gabapentinoid within 3 months before surgery
• History of previous knee surgery
• Severe liver disease

Where it is running

• Thammasat University Hospital — Khlong Luang, Changwat Pathum Thani, Thailand (enrolling)

Full record on ClinicalTrials.gov

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