A Feasibility Study of Supplemental Oxygen to Improve Pulmonary Hypertension in People With Intradialytic Hypoxemia

Starting soon · Phase 1/Phase 2

Conditions studied: Pulmonary Hypertension

In brief

The purpose of this study is to assess the feasibility of supplemental oxygen delivery during hemodialysis in people with pulmonary hypertension and intradialytic hypoxemia.

Key facts

Study ID

NCT06327373

Run by

Duke University

People needed

10

Starts

2026-07-01

Expected to finish

2027-06-30

Last updated by the study team

2025-08-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults ≥18 years
• Receiving Monday-Wednesday-Friday or Tuesday-Thursday-Saturday hemodialysis
• Screened positive for pulmonary hypertension (defined by tricuspid regurgitant velocity [TRV] >2.5 m/s on echocardiography) and intradialytic hypoxemia (defined by spending ≥1/3 treatment with O2 saturation <90%) or hypoxemia for ≥10% of the treatment if associated with a desaturation event (≥4% decline in O2 saturation to <88% for ≥10 seconds) during enrollment in the PH-ESKD study (Pro00108710).

You may not qualify if…

• Daily supplemental oxygen use
• Inability to provide informed consent

Where it is running

• Davita Durham East — Durham, North Carolina, United States
• Davita Durham Downtown — Durham, North Carolina, United States
• Davita Research Triangle Park — Durham, North Carolina, United States
• Davita Durham Regional — Durham, North Carolina, United States
• Davita Durham West — Durham, North Carolina, United States
• Davita Bull City — Durham, North Carolina, United States
• Davita Durham Southpoint — Durham, North Carolina, United States
• Davita Hope Valley — Durham, North Carolina, United States
• Davita Vance County — Henderson, North Carolina, United States
• Davita Kerr Lake — Henderson, North Carolina, United States
• Davita Roxboro — Roxboro, North Carolina, United States

Full record on ClinicalTrials.gov

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