Thiamine Intervention and Coronary Artery Bypass Grafting
Recruiting now · Early Phase 1 · Has a placebo group
Conditions studied: Coronary Heart Disease, Coronary Artery Bypass Grafting
In brief
The purpose of this study is to gain a better understanding of the association between brain changes and cognitive deficits in coronary heart disease (CHD) patients undergoing coronary artery bypass grafting (CABG) and whether a low-cost thiamine intervention can be used to reduce post-CABG cognitive issues in CHD subjects.
Key facts
- Study ID
- NCT06326996
- Run by
- University of California, Los Angeles
- People needed
- 52
- Starts
- 2024-10-10
- Expected to finish
- 2026-09-30
- Last updated by the study team
- 2026-08-03
Who can join
Age: 60 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with Coronary Heart Disease (CHD) scheduled for Bypass Grafting (CABG)
- Thiamine deficiency before CABG
- European System for Cardiac Operative Risk Evaluation II (EuroSCORE II) >1.5%
- Off-pump surgery
You may not qualify if…
- Dementia at baseline [Montreal Cognitive Assessment (MoCA) <21 within 5 days before CABG]
- Current in-take of thiamine
- Known thiamine allergy
- Uncontrolled blood glucose levels
- Unable to give consent due to illness
- History of hyperlactatemia
- Recent (within several years and/or up to the judgment of the PI/co-PIs) cerebral incidents (seizure or head trauma resulting in loss of consciousness and/or concussion)
- Stroke
- Diagnosed psychiatric diseases (clinical depression, schizophrenia, manic-depression)
- Patients with history of alcohol or substance abuse
- Acute or chronic infections (tuberculosis, hepatitis, or encephalopathy)
- Diagnosed neuro-degenerative diseases (Alzheimer's or Parkinson's disease)
- Chronic immunodeficiency (including HIV)
- Congenital brain deficits will also be excluded
Where it is running
- UCLA — Los Angeles, California, United States (enrolling)
Full record on ClinicalTrials.gov
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