A Research Study Comparing How Well Different Doses of the Medicine NN0519-0130 Help People With Excess Body Weight Lose Weight

Completed · Phase 2 · Has a placebo group

Conditions studied: Obesity

In brief

This study will look at how a new medicine called NNC0519-0130 helps people with excess body weight lose weight. The study will test up to 6 different doses of NNC0519-0130. Participants will take 1-2 injections once a week. The study medicine will be injected under skin with a thin needle in the stomach, thigh, or upper arm. The study will last for about 42 weeks.

Key facts

Study ID

NCT06326060

Run by

Novo Nordisk A/S

People needed

354

Starts

2024-03-18

Expected to finish

2025-05-01

Last updated by the study team

2026-04-15

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Female of non-childbearing potential, or male.
• a. For US only: Female of childbearing potential using highly effective non-systemic methods of contraception with low user-dependency at least 2 months prior to screening and willingness to continue using it through-out the study, or male.
• Age 18-75 years (both inclusive) at the time of signing the informed consent.
• History of at least one self-reported unsuccessful dietary effort to lose body weight.
• a) BMI ≥ 27.0 kg/m2 with the presence of at least one weight-related co-morbidity including, but not limited to, hypertension, dyslipidaemia, obstructive sleep apnoea or cardiovascular disease.
• b) BMI ≥ 30.0 kg/m2.

You may not qualify if…

• HbA1c greater than equal to 6.5% (48 millimoles per mole (mmol/mol)) as measured by the central laboratory at screening.
• History of type 1 or type 2 diabetes mellitus.
• Treatment with any medication prescribed for the indication of obesity or weight management within 90 days before screening.

Where it is running

• Arkansas Clinical Research — Little Rock, Arkansas, United States
• Unity Health-Searcy Medical Center — Searcy, Arkansas, United States
• FDRC — Costa Mesa, California, United States
• Encompass Clinical Research_Spring Valley — Spring Valley, California, United States
• UCLA Health Southbay Endocrine — Torrance, California, United States
• Diablo Clinical Research, Inc. — Walnut Creek, California, United States
• Univ of Colorado at Denver — Aurora, Colorado, United States
• Nature Coast Clinical Research — Crystal River, Florida, United States
• Northeast Research Institute — Fleming Island, Florida, United States
• Jacksonville Ctr For Clin Res — Jacksonville, Florida, United States
• South Broward Research LLC — Miramar, Florida, United States
• Cedar-Crosse Research Center — Chicago, Illinois, United States
• Midwest Inst For Clin Res — Indianapolis, Indiana, United States
• Velocity Clin. Res Valparaiso — Valparaiso, Indiana, United States
• L-MARC Research Center — Louisville, Kentucky, United States
• Centennial Medical Group — Columbia, Maryland, United States
• StudyMetrix Research LLC — City of Saint Peters, Missouri, United States
• NYU Bariatric Surgical Ctr — New York, New York, United States
• Rochester Clinical Research, Inc. — Rochester, New York, United States
• Velocity Clinical Res. Inc Vestal — Vestal, New York, United States
• Medication Mgmnt, LLC_Grnsboro — Greensboro, North Carolina, United States
• PharmQuest Life Sciences LLC — Greensboro, North Carolina, United States
• Physicians East Endocrinology — Greenville, North Carolina, United States
• Piedmont Healthcare Statesville — Statesville, North Carolina, United States
• Centricity Research-Arizona — Mesa, Arizona, United States

Full record on ClinicalTrials.gov

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