Exercise MRI to Evaluate Cardiorespiratory Fitness in Children With Heart Disease
Recruiting now
Conditions studied: Pediatric ALL, Congenital Heart Disease, Heart Transplantation
In brief
There are many barriers to heart-healthy lifestyles in pediatric patients with acquired and congenital heart disease. Investigators want to further understand how participants heart and skeletal muscles work together during exercise and evaluate the impact on cardiac function. To do this, the investigators will use magnetic resonance imaging (MRI) to scan the heart and skeletal muscles during exercises to assess blood flow, oxygenation and function.
Key facts
- Study ID
- NCT06325280
- Run by
- University of Alberta
- People needed
- 20
- Starts
- 2025-01-20
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2026-03-16
Who can join
Age: 10 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 10 - 18 year olds followed at the Stollery Children's Hospital
- Heart transplant recipients ≥6 months post-transplant
- Have a moderate-complex congenital heart disease diagnosis
You may not qualify if…
- Non-English speaking
- Exercise restricted by the patient's clinical cardiologist
- Clinical antibody- or cellular-mediated rejection within 3-months of the assessment or during the study period (for HTRs)
- Previous involvement in a CR or exercise intervention program
- Previous exercise stress test demonstrating sustained arrhythmias, ST segment elevation or depression greater than 3mm, an inappropriate rise in blood pressure (BP) (<20 mmHg) or a systolic BP >200 mmHg, or symptoms of chest pain or syncope
- Resting arterial saturation <85% or oxygen requirements
- Moderate ventricular systolic dysfunction (or worse) at the most recent echocardiogram
- History of chest pain on exertion; unrepaired/unpalliated CHD
- Arrhythmias in the last year (including supraventricular tachycardia, ventricular tachycardia, atrioventricular block or history of (Mobitz II or worse))
- New York Heart Association class II or worse symptoms
- Active medical inter-current illness limiting ability to participate
- Cognitive impairment limiting the communication needed for the exercise MRI
- Research MRI contraindications (e.g. any type of pacemaker), or any orthopedic limitation preventing exercise testing
- Extracardiac or congenital abnormality limiting the participant's functional ability to exercise
- Pregnant
Where it is running
- University of Alberta — Edmonton, Alberta, Canada (enrolling)
Full record on ClinicalTrials.gov
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