Longitudinal Monitoring During Intermittent Fasting Protocols in Obese Adults

Recruiting now · Not applicable

Conditions studied: Intermittent Fasting, Obesity, Time Restricted Eating

In brief

LIMITFOOD2 is a randomized clinical intervention study that investigates the effects of two different intermittent fasting protocols compared to a control group on the health of obese adults. A total of 90 participants will be randomized into three equally sized groups: a modified alternate day fasting, a time-restricted eating and a control group, receiving general weight-loss counseling.

Key facts

Study ID

NCT06323889

Run by

University of Zurich

People needed

90

Starts

2024-09-23

Expected to finish

2027-01-01

Last updated by the study team

2024-12-20

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age between 18-50 years, both inclusive
• Obese, BMI between 30 and 40 kg/m\^2 (obesity grade I or II), both inclusive
• Non-smoker
• Good knowledge of German or English language
• Stable weight change (change < +/- 3% current bodyweight) for 3 months prior to the study
• HbA1c < 6.5% without glucose lowering medication
• LDL-cholesterol < 4.6mmol/l without lipid lowering medication

You may not qualify if…

• Participants who have a fasting period of > 12h per day on a regular basis and do not eat at least three main meals per day.
• Current habitual use of dietary supplements (e.g., vitamins, minerals) and/or unwillingness to cease intake of dietary supplements.
• Antibiotics intake during 3 months prior to the study due to possible interference with metabolic parameters
• Food intolerances, allergies and sensitivities (severe food allergies) or dietary restrictions (e.g. vegan lifestyle)
• Acute or chronic infections, malignant disease, renal, hepatic (more than two-fold increased transaminases), pulmonary, neurological (epilepsy) or psychiatric diseases, manifested atherosclerosis, or any other disease precluding participation in the study.
• Diabetes
• Known alcohol, substance or drug abuse, concomitant medication
• More than four hours of physical exercise per week
• Women who are pregnant, breast-feeding or aiming to become pregnant during course of the trial
• Women and men on hormonal supplementation
• Women with an irregular menstrual cycle according to the FIGO criteria
• Therapy with antidepressants within the past 6 months
• Regular therapy with acetylsalicyclic acid or current medication to regulate blood sugar, blood pressure or lipids
• Participants likely to fail to comply with the study protocol
• Participants who do not give informed consent

Where it is running

• Department of Endocrinology, Diabetology and Clinical Nutrition — Zurich, Canton of Zurich, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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