Efficacy and Safety of Oliceridine for Moderate to Severe Acute Pain After Orthopedic Surgery

Recruiting now · Phase 4

Conditions studied: Postoperative Pain

In brief

The goal of this clinical trial\] is to further explore the effectiveness and safety of oxelidine in the treatment of moderate to severe acute pain after orthopedic surgery. The main question it aims to answer is: Pain management after orthopaedic surgery provides more effective and safe drug options, provides new options for clinical treatment, and provides a scientific basis for clinical practice. Participants will be asked to pain score in the different time, treatments they'll be given and use optimal drug. Researchers will compare analgesic effect of oxelidine of different dose.

Key facts

Study ID: NCT06320041
Run by: The Fourth Affiliated Hospital of Zhejiang University School of Medicine
People needed: 162
Starts: 2024-08-01
Expected to finish: 2026-12-31
Last updated by the study team: 2025-02-17

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

elective orthopedic surgery under general anesthesia.
The patient can communicate normally and has the correct expression of pain

You may not qualify if…

Patients with advanced tumor
Other acute and chronic pain conditions are present
Severely obese (30 kg/m2)
Pregnant or lactating women
Allergy to opioids
Sleep apnea syndrome
Long-term opioid treatment
Patients with mental and nervous system diseases, gastrointestinal obstruction, chronic obstructive pulmonary disease or pulmonary heart disease, cardiovascular disease
Abnormal liver function during screening
Abnormal renal function during screening

Where it is running

The Fourth Affiliated Hospital of Zhejiang University School of Medicine — Yiwu, Zhejiang, China (enrolling)

Full record on ClinicalTrials.gov

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