Modified Deep Extubation vs. Standard Awake Extubation

Recruiting now · Not applicable

Conditions studied: Extubation

In brief

The proposed study is to compare a modified DE technique, which is regularly used for low-risk patients by staff anesthesiologists at our institution, to a standard awake extubation. This modified deep extubation (mDE) occurs while the patient is still anaesthetized but at a lower dose of anaesthetic gas than previously described, and balanced with long acting opioids to attenuate the airway reaction. As previously stated, the literature shows that the risks of DE are equivalent to those of regular AE practice. Our hypothesis is that mDE will shorten the time from the end of the surgery (completion of last stitch) to the moment the patient is ready to leave the OR by at least 5 minutes when compared to standard AE practice.

Key facts

Study ID

NCT06318715

Run by

Samuel Lunenfeld Research Institute, Mount Sinai Hospital

People needed

60

Starts

2024-04-08

Expected to finish

2026-12-30

Last updated by the study team

2025-07-09

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ASA I-III
• laparoscopic surgery under general anesthesia

You may not qualify if…

• High-risk patients:
• Documented difficult airway during intubation or developed intraoperatively.
• Full stomach
• Pregnant women
• Emergency surgery
• BMI>30
• Intraoperative bleeding leading to transfusion
• Use of remifentanil during extubation
• Requirement for prone position for surgical approach (i.e., spine surgery, anal fistulectomy, tumor resection of the back, etc)
• Absolute indication for awake or deep extubation
• Use of opioids in chronic pain patients

Where it is running

• Department of Anesthesia Mount Sinai Hospital — Toronto, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

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