Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis

Recruiting now

Conditions studied: Amyotrophic Lateral Sclerosis, Motor Neuron Disease

In brief

The goal of this observational study is to understand the clinical variability in a population of ALS patients using multidimensional biomarkers. The main questions it aims to answer are: * Which set of biomarkers explain genotypic-phenotypic correlations in ALS? * Which set of biomarkers can be used to subdivide the ALS population in homogeneous subgroups? Participants will undergo: * neurological evaluation * neurophysiological evaluation * neuropsychological evaluation * whole exome sequencing * biomarker measurement in CSF and plasma

Key facts

Study ID

NCT06318598

Run by

Istituto Auxologico Italiano

People needed

200

Starts

2023-04-11

Expected to finish

2026-04-10

Last updated by the study team

2025-05-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• diagnosis of ALS or other motor neuron disease
• residence near the study centers

You may not qualify if…

• refusal to participate to the study
• unable/unwilling to perform follow-up visits

Where it is running

• Ospedale San Raffaele — Milan, MI, Italy (enrolling)
• Ospedale San Luca — Milan, MI, Italy (enrolling)
• AOU Città della Salute e della Scienza — Torino, TO, Italy (enrolling)

Full record on ClinicalTrials.gov

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