Pelvic Floor Muscle Training for Women with Myotonic Dystrophy

Recruiting now · Not applicable

Conditions studied: Myotonic Dystrophy Type 1, Urinary Incontinence

In brief

Myotonic dystrophy type 1 (DM1) is a neuromuscular disease characterized by multisystem manifestations. DM1 can affect the urinary system through the impact of the pelvic floor muscles (PFM). Urinary incontinence can occur in this situation and is often offset with compensatory measures without restoring the PFM function (e.g. sanitary pads). PFM training have already been shown to be effective in reducing or even eliminating urinary incontinence in the general population. However, no study has been the subject of this modality in people with DM1. Having recently shown that it is possible to gain strength with DM1, a strengthening protocol targeting PFM could prove effective in treating urinary incontinence. The objectives of this study are i) to assess the feasibility and acceptability of PFM training and ii) to investigate the effects of PFM training in women with DM1 with adult phenotype. A quasi-experimental study will be conducted with 12 women having a confirmed diagnosis of DM1 with urinary incontinence. Participants will follow a 12-week PFM training program, comprising weekly sessions with an experienced physiotherapist as well as a home exercise program. Outcomes measures will be assessed at baseline and at post-treatment and will include: feasibility and acceptability variables, frequency of urinary incontinence, urogynecological symptoms and their impact on quality of life, morphometry and function of PFM, and the perceived improvement following the treatments. This study has the potential to improve the management of urinary incontinence and support the implementation of pelvic floor rehabilitation services in this population.

Key facts

Study ID

NCT06316778

Run by

Université de Sherbrooke

People needed

12

Starts

2024-03-11

Expected to finish

2026-12-30

Last updated by the study team

2025-02-24

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• confirmed medical diagnosis of myotonic dystrophy type 1 (DM1) with adult phenotype
• symptoms of stress, urge or mixed urinary incontinence
• able to give a free and informed consent

You may not qualify if…

• being pregnant, have given birth by vaginal delivery in the last year or plan to become pregnant in the next six months
• present post-void residual urine ≥ 150 ml
• have medical conditions that may have an impact on the symptoms of urinary incontinence and the response to treatments
• present fecal incontinence (≥ 1/week) or significant prolapse (beyond the hymen)
• have already received physiotherapy treatments in pelvic floor rehabilitation or surgery on the perineum
• have a defibrillator, pacemaker or bladder stimulator

Where it is running

• Clinique des maladies neuromusculaires — Jonquière, Quebec, Canada (enrolling)

Full record on ClinicalTrials.gov

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