Predicting Local and Distant Recurrence in T1 Colorectal Cancer

Completed

Conditions studied: Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenocarcinoma, Colorectal Cancer Stage I, Colorectal Neoplasms Malignant, Colorectal Cancer Recurrent

In brief

Tumor recurrence significantly affects survival rates following the local resection of submucosal colorectal cancers (T1 CRC). Despite this, there are currently no reliable biomarkers established to predict recurrence in T1 CRC. This study seeks to improve the prediction of recurrence-free survival in individuals who have survived T1 CRC.

Key facts

Study ID

NCT06314971

Run by

City of Hope Medical Center

People needed

138

Starts

2023-03-15

Expected to finish

2025-06-30

Last updated by the study team

2025-07-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Stage I, pT1 colorectal cancer (TNM classification, 8th edition).
• Received standard diagnostic, staging, and stage-specific curative-intent resection (endoscopic or surgical, as per local guidelines).
• Confirmed cancer-free survivorship at the time of study inclusion.

You may not qualify if…

• Lack of informed consent.
• Induction of neoadjuvant systemic therapy before colorectal cancer resection.
• Synchronous colorectal and non-colorectal cancer diagnosed at or before surgery.

Where it is running

• City of Hope Medical Center — Duarte, California, United States
• Tokushima University — Tokushima, Japan
• Barcelona University — Barcelona, Spain

Full record on ClinicalTrials.gov

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