Transanal Transection and Single-stapled Anastomosis (TTSS) in Rectal Cancer Patients

Recruiting now

Conditions studied: Rectal Cancer, Surgery

In brief

The Transanal Transection and Single-Stapled anastomosis (TTSS) technique may be a valid alternative to traditional double-stapled anastomosis for low rectal cancer surgery. This study aims to compare the postoperative and functional outcomes of patients receiving TTSS and traditional double-stapled anastomosis.

Key facts

Study ID

NCT06314646

Run by

Istituto Clinico Humanitas

People needed

472

Starts

2024-03-26

Expected to finish

2027-12-31

Last updated by the study team

2024-06-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult (≥ 18 years old) patients, men and women, diagnosed with rectal cancer scheduled for elective rectal resection with Total Mesorectal Excision (TME) with double-stapled or Transanal Transection and Single-Stapled anastomosis (TTSS) approaches.
• Patients scheduled for open, laparoscopic, or robotic surgery.
• Patients preoperatively indicated for sphincter-saving procedures with or without protective-stoma.

You may not qualify if…

• Immediate or delayed hand-sewn coloanal anastomosis.
• Patients requiring abdominoperineal resection (APR). Patients undergoing unplanned non-reconstructive surgery will be withdrawn from the study.
• Patients with concurrent or previous invasive pelvic malignant tumors. Patients with an intraoperative evidence of invasive pelvic malignant tumors will be withdrawn from the study.

Where it is running

• IRCCS Humanitas Research Hospital — Rozzano, MI, Italy (enrolling)

Full record on ClinicalTrials.gov

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