Effect of CPAP Treatment in Patients With Severe Uncontrolled Asthma: The ASTHMA-SLEEP Trial

Recruiting now · Not applicable

Conditions studied: Obstructive Sleep Apnea, Asthma

In brief

The aim of the study is to evaluate the impact of CPAP treatment on asthma control in patients with severe uncontrolled asthma and obstructive sleep apnea (OSA)

Key facts

Study ID

NCT06314477

Run by

Hospital Clinic of Barcelona

People needed

138

Starts

2023-12-27

Expected to finish

2026-12-01

Last updated by the study team

2025-12-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age >18 years
• Diagnosis of severe uncontrolled asthma according to the criteria of the Spanish Asthma Management Guide (GEMA) or the Global Initiative for Asthma (GINA) and no hospitalizations the month prior to inclusion in the study.
• Apnea hypopnea rate greater than or equal to 15/hour
• Punctuation in the Epworth Sleepiness Scale ≤10
• Obtaining informed consent.

You may not qualify if…

• Previous treatment with CPAP
• Patient with central sleep apnea or Cheyne-Stokes respiration
• Other sleep disorders: narcolepsy, restless leg syndrome, chronic insomnia,
• Resistant hypertension
• Active Smoking
• Unstable comorbidities or medications may interfere with asthma control
• Pregnancy
• Any process that reduces life expectancy to <1 year,
• Any medical or social factor that may limit CPAP compliance

Where it is running

• Hospital Clinic Barcelona — Barcelona, Spain, Spain (enrolling)

Full record on ClinicalTrials.gov

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