Beyond MARS: Magnetic Resonance Study: A Novel Assessment of Placental Perfusion During Pregnancy

Recruiting now

Conditions studied: Pregnancy

In brief

The purpose of this study is to evaluate the flow of oxygen and blood necessary for nutrient transfer across the placenta during the second and third trimesters in pregnancy in women who are obese before pregnancy compared to women who have an average weight before pregnancy. This study will evaluate blood flow across the placenta by functional Magnetic Resonance Imaging (fMRI). The investigators hypothesize that there will be differences in placental oxygenation and blood flow among women with obesity as compared to those with normal weight. Participants will be asked to complete: * MRI in the second trimester (20-24 weeks) * MRI in the third trimester (30-34 weeks)

Key facts

Study ID

NCT06314009

Run by

Endeavor Health

People needed

30

Starts

2024-05-09

Expected to finish

2026-12-01

Last updated by the study team

2026-03-16

Who can join

Age: 18 and older, up to 60. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Singleton pregnancy, less than 24 weeks gestation
• Pre-pregnancy BMI between 18.5 - 24.9kg/m2 or ≥30kg/m2

You may not qualify if…

• Asthma on controller medication
• Autoimmune Conditions
• Chronic Hypertension
• Claustrophobia
• Congenital Anomaly
• Pregestational Diabetes
• History of Bariatric Surgery
• HIV
• Ineligible for MRI (incompatible implanted medical device)
• Multifetal Gestation
• Smoking during pregnancy

Where it is running

• Endeavor Health — Evanston, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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