First-line Regimen With QL1706 Plus Chemo ± Bev in PDAC Patients

Recruiting now · Phase 2

Conditions studied: Pancreatic Cancer

In brief

This is a multicenter, open-label, exploratory study to evaluate the efficacy and safety of QL1706 plus nab-paclitaxel and gemcitabine with or without bevacizumab as first-line treatment in patients with unresectable locally advanced or metastatic pancreatic cancer

Key facts

Study ID

NCT06313970

Run by

Fudan University

People needed

58

Starts

2024-06-20

Expected to finish

2026-10-31

Last updated by the study team

2025-09-03

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects voluntarily participate in this study, sign the informed consent form;
• Age ≥18 years and ≤75 years;
• Histologically or cytologically confirmed pancreatic ductal adenocarcinoma or adenocarcinoma.
• Patients have not received prior systemic therapy for unresectable locally advanced or metastatic pancreatic cancer;
• At least one measurable lesion according to RECIST 1.1 criteria;
• ECOG Performance Status 0-1;
• Estimated life expectancy ≥3 months;
• Adequate major organ function (no medication for blood component, cell growth factor correction therapy is allowed within 14 days before randomization);
• Women of child-bearing potential must agree to use a reliable, effective method of contraception from the time they provide informed consent until at least 120 days after the last dose of study drug is administered. HCG test must be negative. And must be non-lactating;
• Male participants whose partner is a woman of child-bearing potential must agree to use a reliable, effective method of contraception from the time they sign an informed consent form until at least 120 days after the last dose of study drug is administered. Male subjects also have to agree not to donate sperm during the same period.

You may not qualify if…

• Histologically or cytologically confirmed other pathological types, such as acinar cell carcinoma, pancreatic neuroendocrine neoplasms or pancreatoblastoma.
• Patients with other malignant tumors within 5 years, except localized tumor that has been cured;
• Known active or untreated brain metastases, meningeal metastases, spinal cord compression or leptomeningeal disease.
• Patients with a history of life-threatening bleeding or a definite risk of bleeding within 6 months before randomization;
• Has undergone major trauma or surgical treatment within 28 days before randomization or is expected to undergo major surgical treatment during the study period;
• Poorly controlled hypertension (systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg) ；or have a history of hypertensive crisis or hypertensive encephalopathy;
• Thrombotic or embolic events, such as cerebrovascular accident (including transient ischemic attack, cerebral hemorrhage, cerebral infarction), deep vein thrombosis, pulmonary embolism, etc., occurred within 6 months before randomization;
• Patients who receive any prior treatments targeting the mechanism of tumor immunity, such as immune checkpoint blockades, immune checkpoint agonists, immune cell therapy, etc.
• Active autoimmune disease requiring systemic treatment within 2 years before randomization, or autoimmune diseases that may relapse or require scheduled treatment judged by the investigator;
• Subjects with active hepatitis B or C;
• Patients with a known history of immunodeficiency or HIV positive;
• The investigator assessed that it is not appropriate to participate in the study.

Where it is running

• Fudan University Shanghai Cancer Center — Shanghai, China (enrolling)

Full record on ClinicalTrials.gov

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