Spices for Cultivating a Healthy Gut Microbiome and Cardiometabolic Profile
Status unconfirmed · Not applicable · Has a placebo group
Conditions studied: Cardiometabolic Syndrome
In brief
Among food products receiving attention for prebiotic functionality, spices represent a flavorful vehicle for cultivating a healthy gut microbiota. As the required doses of spice-derived polyphenols to elicit prebiotic and systemic metabolic effects are not well-characterized, additional research is warranted. Thus, the investigators propose to use a food-first synbiotic (prebiotic + probiotic) approach to examine alterations in the gut microbiota pre- and post-intervention/placebo and their relationship with systemic cardiometabolic effects mediated by short chain fatty acids (SCFA) and gut-derived metabolites.
Key facts
- Study ID
- NCT06313580
- Run by
- University of Alabama, Tuscaloosa
- People needed
- 30
- Starts
- 2023-01-01
- Expected to finish
- 2025-06-01
- Last updated by the study team
- 2024-03-20
Who can join
Age: 50 and older, up to 69. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- post-menopausal women ages 50-69y with a BMI of 18.5 - 34.9 kg/m2
You may not qualify if…
- Dx - Diagnosis of cardiovascular disease, type 1 or 2 diabetes, liver disease, cancer, endocrine disorders, or inflammatory condition such as rheumatoid arthritis.
- GI - History of gastrointestinal surgery, irritable bowel syndrome, intestinal bowel disease, or other gastrointestinal distress such as chronic diarrhea, bulimia, anorexia, or frequent laxative use
- Rx or Supplements - Actively taking steroids or antibiotics in the previous two to three months, or currently using tobacco products, > 10% weight loss or gain in the last 6 months, unwilling to stop taking prebiotic/probiotic or fiber supplements
- Dietary - Adherence to a high fiber/polyphenol rich diet, have an allergy, aversion, or intolerance to food and spices provided in this study
Where it is running
- The University of Alabama — Tuscaloosa, Alabama, United States (enrolling)
Full record on ClinicalTrials.gov
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