Multidimensional Evaluation of Patients' Affected by Obstructive Apnea Syndrome (OSAS) Before and After Ventilotherapy

Recruiting now

Conditions studied: Obstructive Sleep Apnea, Sleep Disorder, Well-Being, Psychological, Cognitive Impairment, Cognitive Change, Neurologic Signs

In brief

This observational study aims to evaluate multiple dimensions of health in patients with Obstructive Sleep Apnea Syndrome (OSAS), before and after three weeks of ventilotherapy. Specifically, the study aims to identify pre- vs post-treatment differences in the following domains: * cognitive performance * blood expression of biomarkers related to neurodegeneration * psychosocial wellbeing Thus, patients will complete the following evaluations before (T0) and after (T1) ventilotherapy: * neuropsychological standard assessment * blood sampling * psychosocial self-reported questionnaires

Key facts

Study ID

NCT06312956

Run by

Istituto Auxologico Italiano

People needed

65

Starts

2024-02-29

Expected to finish

2026-12-01

Last updated by the study team

2025-09-09

Who can join

Age: 20 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• OSAS diagnosis (AHI > 5)
• handedness: right

You may not qualify if…

• previous ventilotherapy
• neurological and/or neurodegenerative conditions
• Personality disorders, autism spectrum disorders, schizophrenia, psychosis
• sleep disorders comorbidities (eg., narcolepsy)

Where it is running

• IRCCS Istituto Auxologico Italiano — Piancavallo, VCO, Italy (enrolling)

Full record on ClinicalTrials.gov

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