Novel Approaches for Improving Vascular Function in Veterans With HFpEF

Recruiting now · Phase 1 · Has a placebo group

Conditions studied: Heart Failure With Preserved Ejection Fraction, Inflammation

In brief

This project will evaluate the impact of L-Citrulline, tetrahydrobiopterin (BH4), and atorvastatin administration on physical capacity and vascular function in Veterans with heart failure with preserved ejection fraction (HFpEF).

Key facts

Study ID

NCT06312748

Run by

VA Office of Research and Development

People needed

90

Starts

2021-05-19

Expected to finish

2030-09-30

Last updated by the study team

2026-04-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or older and able to give written informed consent.
• New York Heart Association (NYHA) functional class I, II, or III.
• Left Ventricular Ejection Fraction (LVEF) > 50%.
• Plasma Brain Natriuretic Peptide (BNP) equal to or greater than 150 pg/mL or NT-proBNP equal to or greater than 600 pg/mL at Visit 1, or a BNP equal to or great than 100 pg/mL (or NT-proBNP equal to or greater than 400 pg/mL) and a hospitalization for heart failure within the last 12 months.

You may not qualify if…

• History of hypersensitivity or allergy to any lipophilic statin.
• Prior EF <50%.
• NYHA Class IV.
• Patients with HFpEF secondary to significant uncorrected primary valvular disease.
• Active liver disease or unexplained persistent elevations in serum transaminase.
• Women who are pregnant or may become pregnant.
• Patients currently treated with antioxidants, nitrates, PDE-5 inhibitors, or statins.

Where it is running

• VA Salt Lake City Health Care System, Salt Lake City, UT — Salt Lake City, Utah, United States (enrolling)

Full record on ClinicalTrials.gov

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