First Time in Human Study of Long Acting VH4524184 Formulations

Recruiting now · Phase 1 · Has a placebo group

Conditions studied: HIV Infections

In brief

The purpose of this study is to identify 1 or more doses of parenterally administered VH4524184 that are safe, well tolerated and yield a PK drug exposure profile necessary to deliver a long-acting antiretroviral therapy for the treatment of HIV-1 infection.

Key facts

Study ID

NCT06310551

Run by

ViiV Healthcare

People needed

372

Starts

2024-03-21

Expected to finish

2028-01-21

Last updated by the study team

2026-06-30

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age
• Participant must be 18 to 55 years of age inclusive, at the time of signing the informed consent.
• Type of Participant and Characteristics
• Participants who are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, and cardiac monitoring.
• Participants who are negative for SARS-CoV-2, performed on admission/readmission to the Phase 1 unit, using an approved molecular test (PCR).
• Participants who are able to understand and comply with protocol requirements and timetables, instructions, and protocol-stated restrictions.
• Weight
• Body weight ≥50.0 kg (110 lbs) for men and ≥45.0 kg (99 lbs) for women and body mass index within the range 18.5 to 32.0 kg/m\^2 (inclusive) for all cohorts except B19. For Cohort B19, body mass index within the range >32.0 to 37.0 kg/m\^2 (inclusive).
• Sex and Contraceptive/Barrier Requirements
• Male or female
• Male Participants: No restrictions for male participants
• Participants of female sex assigned at birth:
• A participant of childbearing potential (POCBP) (female sex assigned at birth) is eligible to participate as long as the participant is not pregnant, breastfeeding and utilizes a highly effective method of contraception.
• A participant of non-childbearing potential (PONCBP) is eligible to participate if all other eligibility criteria are met.
• Informed Consent
• Capable of providing signed informed consent.

You may not qualify if…

• Medical Conditions
• History or presence of clinical condition or disorder that could be capable of significantly altering the absorption, metabolism, or elimination of drugs; constituting a risk when taking the study drug, interfering with the interpretation of data or would make the participant unsuitable for the study; unable to comply with dosing requirements; or unable to comply with study visits.
• Clinically significant abnormal blood pressure as determined by the investigator.
• Lymphoma, leukemia, or any malignancy within the past 5 years except for basal cell or squamous epithelial carcinomas of the skin that have been resected with no evidence of metastatic disease for 3 years.
• Breast cancer within the past 10 years.
• Current or chronic history of liver disease or known hepatic or biliary abnormalities.
• Medical history of cardiac arrhythmias or cardiac disease or a family and personal history of long QT syndrome.
• Underlying skin disease or disorder that would interfere with the administration of study product and/or assessment of injection site reactions.
• Clinically significant history of drug hypersensitivity, delayed-type hypersensitivity or severe hypersensitivity reactions, as well as history of /sensitivity to any of the study interventions including hyaluronidases.
• Current or anticipated need for chronic anti-coagulation except for the use of low dose acetylsalicylic acid (≤325 mg) or hereditary coagulation and platelet disorders such as hemophilia or Von Willebrand Disease.
• History of seizure.
• Any known or suspected pre-existing psychiatric condition, including depression, anxiety and insomnia/sleep disturbances, at the discretion of the investigator.
• Any positive (abnormal) response confirmed by the investigator or clinician (or qualified designee) administered C-SSRS at screening.
• Insufficient muscle mass (gluteus medius or thigh) to support IM dose administration in the opinion of the investigator.
• Presence of tattoos, implants or skin piercings that may interfere with the administration of study product and/or assessment of ISRs, if they occur.
• History of or on-going high-risk behaviors that may put the participant at increased risk for HIV acquisition in the opinion of the investigator. This includes participants in HIV discordant relationships, or men who report current or prior unprotected anal sex with other men and those reporting prior or current injecting drug use.
• Prior/Concomitant Therapy
• Past or intended use of over-the-counter or prescription medication within 7 days (or 14 days if the drug is a potential enzyme inducer) or 5 half-lives (whichever is longer) prior to dosing and for the duration of the study.
• Receipt of any live vaccine(s) or vaccines against SARS-CoV-2 within 28 days prior to screening or 14 days before or after scheduled SC or IM dosing.
• Prior/Concurrent Clinical Study Experience
• Exposure to more than 4 new investigational products (including long-acting investigational products) within 12 months prior to the first dosing day.
• Current enrollment or past participation in another investigational study in which an investigational intervention was administered within the last 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product before signing of consent (OR screening) any other clinical study.
• Participation in the study would result in loss of blood in excess of 500 mL over a 56-day period.
• Current enrollment or past participation in this clinical study, with the exception of participants who previously completed the Oral Lead In (OLI) but for operational or logistic reasons did not progress to CRU admission and receipt of injectable suspension for injection (SFI) or powder for suspension for injection (PFS) study medication or placebo, or prior participation in study 218803.
• Diagnostic Assessments

Where it is running

• GSK Investigational Site — Lenexa, Kansas, United States (enrolling)
• GSK Investigational Site — San Antonio, Texas, United States (enrolling)
• GSK Investigational Site — Salt Lake City, Utah, United States (enrolling)

Full record on ClinicalTrials.gov

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