Little Cigar Oxidants
Recruiting now · Not applicable
Conditions studied: Tobacco Use, Oxidative Stress
In brief
Determine the effects of little cigars on human exposure to tobacco smoke oxidants. In a balanced randomized cross-over study design in cigarette smokers, subjects will be assigned to 3 exposure groups. These include a high oxidant little cigar exposure condition, a low oxidant little cigar exposure condition, and their usual cigarette. Biological samples will be collected before and after product usage.
Key facts
- Study ID
- NCT06310187
- Run by
- Milton S. Hershey Medical Center
- People needed
- 50
- Starts
- 2026-03-25
- Expected to finish
- 2029-08-01
- Last updated by the study team
- 2026-06-16
Who can join
Age: 21 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Aged 21 - 65 years old
- Daily cigarette smoker (>= 1 cigarette per day);
- Smoke regular, filtered cigarettes or machine rolled cigarettes with a filter
- No current or past use of Little Cigars
- All other forms of nicotine must be used <6 days out of the past 30 days.
- Able to read and write in English
- No serious cigarette smoking quit attempt or use of any FDA-approved smoking cessation medication in the prior 30 days
- No plan to quitting smoking in the next 3 months
You may not qualify if…
- Women who are pregnant and/or nursing or trying to become pregnant
- Unstable or significant medical condition in the past 3 months (e.g., recent heart attack or other serious heart condition, stroke, severe angina)
- Respiratory diseases (e.g., exacerbations of asthma or Chronic Obstructive Pulmonary Disease (COPD), require oxygen, require oral prednisone), kidney (e.g., dialysis) or liver disease (e.g., cirrhosis), severe immune system disorders (e.g., uncontrolled HIV/AIDS, multiple sclerosis symptoms) or any medical disorder/medication that may affect participant safety or biomarker data
- Uncontrolled substance abuse or inpatient treatment for that condition in the past 6 months
- Exhaled Carbon Monoxide (CO) measurement of >= 17 parts per million
Where it is running
- Penn State College of Medicine — Hershey, Pennsylvania, United States (enrolling)
Full record on ClinicalTrials.gov
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