Hyaluronic Acid and Polynucleotides for Supra-bony Defects

Recruiting now · Not applicable

Conditions studied: Periodontal Diseases, Wound Heal, Periodontal Inflammation, Periodontal Pocket, Periodontal Attachment Loss

In brief

The goal of this pilot study is to describe the early wound healing molecular events and the vascularization pattern associated with the treatment of supra-bony defects with access flap alone or in association with a combined formulation of hyaluronic acid and polydeoxyribonucleotides gel.

Key facts

Study ID

NCT06309719

Run by

Queen Mary University of London

People needed

24

Starts

2024-10-21

Expected to finish

2026-12-01

Last updated by the study team

2026-07-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Systemically healthy males and females ≥18 years old
• Stage III or IV periodontitis (Papapanou, Sanz et al. 2018)
• Presence of supra-bony periodontal defects (i.e., defects where the base of the pocket is located coronal to the alveolar crest and characterized by a predominantly horizontal pattern of tissue destruction) confirmed clinically and radiographically at a minimum of two and a maximum of four adjacent teeth and with a probing pocket depth (PPD) > 5 mm, following non-surgical periodontal therapy (NSPT). If >4 adjacent teeth exhibited the above clinical and radiographic conditions, the four adjacent teeth showing the greatest overall loss of periodontal attachment were included. Wisdom teeth and second molars will not be considered for the study.
• If defect presents with an intrabony component, this should be ≤2 mm.
• Non-surgical periodontal treatment (step 1 and 2) completed within the previous 4 months
• Full-mouth bleeding score (FMBS) and full-mouth plaque score (FMPS) ≤20%

You may not qualify if…

• Teeth with degree III mobility
• Multi-rooted teeth with grade ≥2 furcation involvement
• Heavy smokers (≥10 cigarettes a day)
• Untreated caries or endodontic lesions or abscesses on the teeth involved in the surgery
• Previous periodontal surgery in the area selected for the study
• History of conditions requiring prophylactic antibiotic coverage prior to invasive dental procedures (e.g., mitral valve prolapse, artificial heart)
• Antibiotic or anticoagulant therapy during the month preceding the baseline exam.
• History of alcohol or drug abuse
• Medical history that includes uncontrolled diabetes or hepatic or renal diseases, or other serious medical conditions that can have a negative impact on the periodontal condition
• In treatment with medications that can severely affect bone metabolism and blood clot formation (e.g., anticoagulants, long-term corticosteroids, bisphosphonates, immunosuppressants)
• Self-reported pregnancy or lactation.

Where it is running

• Barts Health NHS Trust Dental Hospital — London, United Kingdom (enrolling)
• Centre for Oral Clinical Research (COCR) — London, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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