Assessing the Convenience of Natural Proliferative Phase Frozen Embryo Transfer

Recruiting now

Conditions studied: Frozen Embryo Transfer

In brief

This study will assess the convenience of the natural proliferative phase frozen embryo transfer (NPP-FET) in terms of number of number of appointments needed before cycle scheduling.

Key facts

Study ID

NCT06307184

Run by

Instituto Valenciano de Infertilidade de Lisboa

People needed

530

Starts

2024-02-23

Expected to finish

2026-12-01

Last updated by the study team

2026-02-23

Who can join

Age: 18 and older, up to 49. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Endometrial thickness ≥ 7 mm on the day of starting progesterone-based luteal phase support (LPS)
• Serum progesterone levels <1.5 ng/ml on the day of starting progesterone-based LPS
• LPS with micronized progesterone 400mg b.i.d.
• Regular cycles (>24 days, ≤ 38 days)
• IVF/ICSI with donated oocytes
• Single blastocyst stage embryo transfer
• First or second embryo transfer from the same cohort

You may not qualify if…

• Use of exogenous ovarian stimulation during FET
• Untreated hydrosalpinx, polyp, submucous myomas or severe adenomyosis
• Recurrent pregnancy loss (≥ 3 previous pregnancy losses)
• Recurrent implantation failure with embryos from oocyte donation (≥ 3 previous failed embryo transfers)
• Personalized initiation of exogenous progesterone according to a previous endometrial receptivity assay test

Where it is running

• Instituto Valenciano de Infertilidade — Lisbon, Portugal (enrolling)

Full record on ClinicalTrials.gov

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