RECOVER-AUTONOMIC: Platform Protocol, Appendix A (IVIG)

Completed · Phase 2 · Has a placebo group

Conditions studied: Long COVID, Long Coronavirus Disease 2019 (Covid19), Long Covid-19

In brief

This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent treatment plans. This protocol is a prospective, multi-center, multi-arm, randomized, controlled platform trial evaluating various interventions for use in the treatment of autonomic dysfunction symptoms, including cardiovascular complications and postural orthostatic tachycardia syndrome (POTS), in Post-Acute Sequelae of SARS-CoV-2 infection (PASC) participants. The interventions tested will include non-pharmacologic care and pharmacologic therapies with study drugs.

Key facts

Study ID

NCT06305793

Run by

Kanecia Obie Zimmerman

People needed

200

Starts

2024-05-08

Expected to finish

2026-06-22

Last updated by the study team

2026-07-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• See NCT06305780 for RECOVER-AUTO: Platform Protocol level inclusion criteria which applies to this appendix (or sub-study)
• Additional Appendix A (IVIG Sub-study) Level Inclusion Criteria:
• Abnormal active standing test defined as presence of orthostatic tachycardia (an increase of 30 beats per minute (bpm) or more in HR within 10 minutes upon standing without orthostatic hypotension) and experiencing orthostatic symptoms
• COMPASS-31 Score > 40

You may not qualify if…

• See NCT06305780 for RECOVER-AUTO: Platform Protocol level exclusion criteria which applies to this appendix (or sub-study)
• Additional Appendix A (IVIG Sub-study) Level Exclusion Criteria:
• Current or previous IVIG treatment
• Contraindication to intravenous immunoglobulin.
• Known allergic reactions to blood products including IVIG and/or subcutaneous immunoglobulin (SCIG), such as history of clinically relevant hemolysis after IVIG infusion, aseptic meningitis, recurrent severe headache, hypersensitivity, severe generalized or severe local skin reactions
• Selective IgA deficiency
• Current and recent (within 5 half-lives) use of high-dose corticosteroids (for example for prior solid organ transplant), omalizumab, anti-TNF-alpha inhibitors
• Use of immunosuppressants such as Plaquenil, or low-dose steroid (prednisone, no more than 10mg a day) will be excluded unless the participant is on stable (>4 weeks) dose
• Significant thrombotic events after the acute phase of COVID-19 and/or within 6 months of enrollment
• Veins that are not viable for infusions
• Not willing to adhere to dosing schedule for IVIG infusions for 9 months

Where it is running

• All sites listed under NCT06305780 — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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