Defining Treatment Outcomes and Genetic Architecture in Idiopathic Toe Walking*

Completed · Not applicable

Conditions studied: Idiopathic Toe Walking

In brief

To compare and contrast the clinical, gait and parent-reported outcomes following either non-operative (casting) or operative treatment for children with idiopathic toe walking (ITW) and determine whether there are specific genes associated with ITW.

Key facts

Study ID: NCT06305689
Run by: Shriners Hospitals for Children
People needed: 65
Starts: 2022-01-01
Expected to finish: 2025-12-31
Last updated by the study team: 2026-01-14

Who can join

Age: 6 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Diagnosis of Idiopathic Toe Walking Persistent (ITWp)
Between the ages of 6-18 years
Passive dorsiflexion dorsiflexion with knee extension between -10 plantar flexion - + 5 degrees of dorsiflexion, DiGiovanni defined an isolated gastrocnemius contracture as maximum passive ankle dorsiflexion as < 5 degrees with the knee in full extension

You may not qualify if…

Diagnosis of Autism or autism spectrum disorder
Presence of any indicators of trauma, neuromuscular influence or neurogenic influence as identified by using the Toe Walking Tool

Where it is running

Shriners Hospitals for Children — Sacramento, California, United States
Shriners Hospitals for Children — Chicago, Illinois, United States
Shriners Hospitals for Children — Lexington, Kentucky, United States
Shriners Hospitals for Children — Portland, Oregon, United States
Shriners Hospitals for Children — Philadelphia, Pennsylvania, United States
Shriners Hospitals for Children — Greenville, South Carolina, United States
Shriners Hospitals for Children — Salt Lake City, Utah, United States
Shriners Children's Spokane — Spokane, Washington, United States

Full record on ClinicalTrials.gov

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