Effect of Blue Light on Vagus Nerve Stimulation in Patients With Refractory Epilepsy

Recruiting now · Not applicable

Conditions studied: Refractory Epilepsy

In brief

Vagus nerve stimulation (VNS) is an adjunctive treatment for refractory epilepsy. Although widely used, there is still a substantial number of patients with insufficient response. Light, and particularly blue light, can stimulate alertness, attention and cognition through modulation of anatomical targets which are common to the vagal afferent network. This project aims at understanding how exposure to blue enriched light may influence VNS effects in patients with refractory epilepsy by exploring the modulation of a series of biomarkers of VNS action. This could possibly lead to new therapeutic strategies to increase efficacy of VNS.

Key facts

Study ID

NCT06304389

Run by

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

People needed

34

Starts

2023-07-01

Expected to finish

2026-04-01

Last updated by the study team

2025-09-10

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients:
• VNS implanted since at least 3 months age >18-60 years; IQ >55 on Wechsler scale (normal status or mild cognitive impairment)
• healthy participants aged between 18 and 35 years without any medical history (neurological / psychiatric disease)

You may not qualify if…

• Patients:
• other medical implanted devices than VNS, ocular diseases
• Helthy participants:
• medical implanted devices, cerebral trauma, ocular disease

Where it is running

• Cliniques Universitaires Saint Luc — Woluwe-Saint-Lambert, Belgium (enrolling)

Full record on ClinicalTrials.gov

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