A Trial to Learn How Well REGN9933 and REGN7508 Work for Preventing Blood Clots, and How Safe They Are, in Adults Who Have a Peripherally Inserted Central Catheter (PICC)
Completed · Phase 2 · Has a placebo group
Conditions studied: Venous Thromboembolism
In brief
This study is researching 2 different experimental drugs called REGN9933 and REGN7508 (called "study drugs"). The study is focused on adults undergoing a placement of a catheter in the vein, also called a 'PICC line'. The aim of the study is to see how effective the study drug is at preventing venous thromboembolism (VTE) and other related disease after catheter placement. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects)
Key facts
- Study ID
- NCT06299111
- Run by
- Regeneron Pharmaceuticals
- People needed
- 195
- Starts
- 2024-09-20
- Expected to finish
- 2026-03-27
- Last updated by the study team
- 2026-04-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Cedars-Sinai Medical Center — Los Angeles, California, United States
- Sylvester Comprehensive Cancer Center — Miami, Florida, United States
- Brigham and Women's Hospital — Boston, Massachusetts, United States
- Henry Ford Health System — Detroit, Michigan, United States
- Mount Sinai Medical Center — New York, New York, United States
- Memorial Sloan Kettering — New York, New York, United States
- Sveta Sofia Hospital — Sofia, Bulgaria
- Juravinski Hospital — Hamilton, Ontario, Canada
- London Health Sciences Centre — London, Ontario, Canada
- Lakeridge Health — Oshawa, Ontario, Canada
- University Health Network — Toronto, Ontario, Canada
- Shaare Zedek Medical Center — Jerusalem, Jerusalem, Israel
- Soroka University Medical Center — Beersheba, Southern District, Israel
- Hadassah University Medical Center — Jerusalem, Israel
- Lanadio Medical Center — Netanya, Israel
- Rabin Medical Center — Petah Tikva, Israel
- Sheba Medical Center — Ramat Gan, Israel
- Tel Aviv Sourasky Medical Center — Tel Aviv, Israel
- Arensia Research Clinic — Bucharest, Romania
- Arensia Exploratory Medicine Clinic at Country Hospital Cluj-Napoca — Cluj-Napoca, Romania
- University hospital Southampton — Southampton, Hampshire, United Kingdom
- Cardiff and Vale University Health Board - University Hospital Wales — Cardiff, Wales, United Kingdom
- The Newcastle Upon Tyne Hospitals NHS Foundation Trust — Newcastle upon Tyne, United Kingdom
Full record on ClinicalTrials.gov
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