A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weight Loss, Fat Loss, and Lean Mass Preservation
Running, not enrolling · Phase 2 · Has a placebo group
Conditions studied: Obesity
In brief
This study is researching experimental drugs called trevogrumab and garetosmab (called "study drugs") in combination with another drug, semaglutide (Wegovy®). This study will be done in 3 parts, Part A, Part B, and Part C where different study drugs will be tested. Part A of the study is focused on healthy participants. Part B and C of the study is focused on participants with obesity. The aim of Part A of the study is to see how safe and tolerable the study drug is in healthy participants. The aim of Part B and Part C of the study is to see how safe and effective the study drug is when combined with Wegovy. Parts A, B, and C of the study are looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)
Key facts
- Study ID
- NCT06299098
- Run by
- Regeneron Pharmaceuticals
- People needed
- 1005
- Starts
- 2024-03-13
- Expected to finish
- 2026-10-30
- Last updated by the study team
- 2026-07-21
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
Where it is running
- Cullman Clinical Trials — Cullman, Alabama, United States
- Foothills Research Center Cct Research — Phoenix, Arizona, United States
- Anaheim Clinical Trials — Anaheim, California, United States
- ProSciento — Chula Vista, California, United States
- Valiance Clinical Research- Huntington Park — Huntington Park, California, United States
- Velocity, San Diego — La Mesa, California, United States
- Northern California Research — Sacramento, California, United States
- Acclaim Clinical Research — San Diego, California, United States
- Metabolic Institute of America — Tarzana, California, United States
- Valiance Clinical Research — Tarzana, California, United States
- Southwest General Healthcare Center — Fort Myers, Florida, United States
- Westside Center for Clinical Research — Jacksonville, Florida, United States
- Jacksonville Center for Clinical Research — Jacksonville, Florida, United States
- IMA Clinical Research St. Petersburg — St. Petersburg, Florida, United States
- Precision Clinical Research, LLC — Sunrise, Florida, United States
- Clinical Research of West Florida, Inc. — Tampa, Florida, United States
- Clinical Research of Central Florida - Bond Clinic — Winter Haven, Florida, United States
- Center for Advanced Research and Education — Gainesville, Georgia, United States
- Balanced Life Health Care Solutions — Lawrenceville, Georgia, United States
- North Georgia Clinical Research — Woodstock, Georgia, United States
- East-West Medical Research Institute — Honolulu, Hawaii, United States
- Elite Clinical Trials LLLP — Blackfoot, Idaho, United States
- Prairie Education and Research Cooperative (PERC) — Springfield, Illinois, United States
- The South Bend Clinic Center for Research — South Bend, Indiana, United States
- Pinnacle Research Group — Anniston, Alabama, United States
Full record on ClinicalTrials.gov
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