Evaluating the Effect Of Rifaximin on the Gut Microbiota and Metabolome in SIBO Using CapScan®

Recruiting now · Phase 1

Conditions studied: Small Intestinal Bacterial Overgrowth

In brief

We will sample intestinal microbiota using a microbiome sampling capsule in patients with Small Intestinal Bacterial Overgrowth (SIBO)

Key facts

Study ID

NCT06298409

Run by

Envivo Bio Inc

People needed

34

Starts

2024-02-15

Expected to finish

2026-02-28

Last updated by the study team

2025-06-11

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males or females 18 years of age or older and 80 years of age or younger at the time of the first Screening Visit.
• ASA Classification 1 or 2.
• For women of childbearing potential, negative urine pregnancy test within 7 days of Screening Visit.
• Willingness to use highly effective contraception during the entire study period (e.g.: implants, injectables, oral contraceptives, intra-uterine device or declared abstinence).
• Subject is fluent in English and understands the study protocol and informed consent and is willing and able to comply with study requirements and sign the informed consent form.
• Positive for at least one clinical symptom consistent with SIBO.
• Positive lactulose breath test for SIBO, by Hydrogen (H2) criteria.
• Prescribed, but has not started, a two-week course of Rifaximin for SIBO.

You may not qualify if…

• History of any of the following: Prior gastric or esophageal surgery, including lap banding or bariatric surgery, bowel obstruction, gastric outlet obstruction, diverticulitis, inflammatory bowel disease, ileostomy or colostomy, gastric or esophageal cancer, achalasia, esophageal diverticulum, active dysphagia or odynophagia.
• Actively taking a proton-pump-inhibitor medication within 30 days of enrollment
• Pregnancy or planned pregnancy within 30 days from Screening Visit, or breast-feeding
• Any form of active substance abuse or dependence (including drug or alcohol abuse), unstable medical or psychiatric disorder, or any chronic condition susceptible, in the opinion of the investigator, to interfere with the conduct of the study
• A clinical condition that, in the judgment of the investigator, could potentially pose a health risk to the subject while involved in the study

Where it is running

• Silicon Valley Gastroenterology — Mountain View, California, United States (enrolling)

Full record on ClinicalTrials.gov

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