Biomarkers for Peripheral Circadian Clocks in Humans
Recruiting now · Not applicable
Conditions studied: Circadian Rhythms
In brief
The purpose of this project is to improve our understanding of peripheral circadian rhythms in humans. Circadian clocks are present in most tissues of the body with importance for optimal physiological function, health, and behavior. This project will utilize simulated jetlag protocols to systematically test novel hypotheses about the regulation of peripheral circadian rhythms in humans. Specifically, we will examine how changes in the time of when we are exposed to light and the timing of when we eat impacts proteins in the blood and saliva that represent rhythms from clocks in the brain (e.g., rhythms of the hormones melatonin and cortisol coordinated by the brain) and rhythms from clocks in body tissues (e.g., proteins made by immune and bone cells, and cells in the stomach and liver). We also aim to discover new blood-based biomarkers of peripheral rhythms in humans. We anticipate our findings will be the first step in developing novel circadian based treatments for aligning peripheral clocks under conditions such as jetlag, and for developing novel circadian biomarkers that will advance our scientific understanding of circadian rhythms.
Key facts
- Study ID
- NCT06296823
- Run by
- University of Colorado, Boulder
- People needed
- 14
- Starts
- 2023-09-01
- Expected to finish
- 2027-08-31
- Last updated by the study team
- 2026-06-17
Who can join
Age: 17 and older, up to 35. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 17-35 years old 2) English speaking 3) Healthy 5) Altitude history: Currently residing at Denver altitude or higher
You may not qualify if…
- Any medical, psychiatric, or sleep disorder.
Where it is running
- Sleep and Chronobiology Laboratory — Boulder, Colorado, United States (enrolling)
Full record on ClinicalTrials.gov
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