A Comparative Clinical Study to Assess Pain Score and Wound Healing Following Fractional Ablation With a DFG Laser and CO2 Laser

Recruiting now · Not applicable

Conditions studied: Healthy

In brief

This research study aims assess whether the Difference Frequency Generation (DFG) laser could be a better alternative to the CO2 laser in terms of reduced side effects and patient downtime.

Key facts

Study ID

NCT06295471

Run by

Massachusetts General Hospital

People needed

23

Starts

2024-10-16

Expected to finish

2027-03-01

Last updated by the study team

2026-04-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subjects must be able and willing to provide written informed consent and comply with the requirements of the study protocol;
• Subjects must be in good general health, based on answers provided during the screening visit;
• Subjects must be able to read and understand English.
• Subjects must be above the age of 18.
• Subjects must have no history of skin conditions that affect the integrity of the skin barrier.

You may not qualify if…

• Are pregnant or lactating;
• Have a history of drug or alcohol abuse or have reported habitual alcohol intake greater than 2 standard drinks per day [e.g., 2 beers, 2 glasses of wine, or 2 mixed drinks];
• Are smoking or have a history of smoking;
• Presence of eczema, psoriasis, skin wounds or ulcers, or any other skin disease on the thighs;
• Have birth marks, tattoos, scars, or any other disfiguration of the skin in the skin area of interest;
• Presence of sunburn or tan in the treatment area;
• Use of any topical application of retinoids in the area of interest or systemic retinoids in the past 6 months;
• Use of any prescription topical medication, such as corticosteroids or hydroquinone on the skin area of interest in the past 6 months;
• History of blood-clotting abnormality;
• History of keloid formation or hypertrophic scarring;
• History of allergic reaction to local anesthesia, aluminum chloride, and/or glycerol;
• Investigator, interfere with study evaluations or pose a risk to subject safety during the study;
• Exhibits any clinical conditions or takes any medication which in the opinion of the investigator may interfere with the study or pose a risk to subject safety during the study;
• Is not able to follow study protocol.

Where it is running

• MGH Clinical Unit for Research Trials & Outcomes in Skin — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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