The Optimal Antibiotic Treatment Duration for Community-acquired Pneumonia in Adults Diagnosed in General Practice in Denmark (CAP-D)

Recruiting now · Phase 4

Conditions studied: Community-acquired Pneumonia

In brief

The aim of this randomised controlled trial is to identify the optimal treatment duration with phenoxymethylpenicillin for community-acquired pneumonia diagnosed in general practice. Eligible participants are adults (≥18 years) presenting in general practice with symptoms of an acute LRTI (i.e., acute illness (≤ 21 days) usually with cough and minimum one other symptom such as dyspnea, sputum production, wheezing, chest discomfort or fever) in whom the GP finds it relevant to treat with antibiotics. Consenting patients who meet all the eligibility criteria will be randomised (1:1:1:1:1) to either three, four, five, six or seven days of treatment with phenoxymethylpenicillin 1.2 MIE four times daily.

Key facts

Study ID

NCT06295120

Run by

Research Unit for General Practice in Aalborg

People needed

600

Starts

2023-11-13

Expected to finish

2026-03-31

Last updated by the study team

2025-08-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Eligible participants are adults (≥18 years) presenting in general practice with symptoms of an acute LRTI (i.e., acute illness (≤ 21 days) usually with cough and minimum one other symptom such as dyspnoea, sputum production, wheezing, chest discomfort or fever) in whom the GP finds it relevant to treat with antibiotics.

You may not qualify if…

• Need for immediate hospitalisation at the time of diagnosis.
• Known allergy to beta-lactam antibiotics.
• Any coinfection necessitating antibiotic treatment.
• Use of systemic antibiotics or antivirals within the last month.
• Pre-existing lung disease (e.g., chronic obstructive pulmonary disease, bronchiectasis, asthma, lung cancer).
• Known immunosuppression (i.e., long term treatment with corticosteroid, chemotherapy, or immune disorder).
• Pregnant or lactating.
• Patients not capable of consenting and/or patients deemed non-suitable for participation by the healthcare professional.

Where it is running

• The Research Unit for General Practice Aalborg — Gistrup, Denmark (enrolling)

Full record on ClinicalTrials.gov

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