Evaluation of Free Gingival Graft Timing

Recruiting now · Not applicable

Conditions studied: Ridge Augmentation, Alveolar Mucosa

In brief

This clinical trial aims to compare and evaluate the clinical outcomes between two distinct treatment sequences: free gingival graft surgery preceding guided bone regeneration and guided bone regeneration followed by free gingival graft.

Key facts

Study ID

NCT06294587

Run by

University of Alabama at Birmingham

People needed

30

Starts

2024-08-12

Expected to finish

2027-08-30

Last updated by the study team

2025-08-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• • At least 18 years old
• No uncontrolled medical conditions or medications that will affect their bone healing.
• Good oral hygiene is defined as a full-mouth plaque score ≤25%11.
• Must be able to read and understand the informed consent document.
• Has a need for implants to replace missing tooth/teeth in at least 1 quadrant of the mouth.
• Insufficient alveolar ridge width for endosseous implant placement, defined as 5 mm or less, as determined by bone sounding and CBCT scan.
• The patient and/or guardian is willing and able to comply with pre-operative and post-operative diagnostic and clinical evaluations required.
• The patient is not pregnant or breastfeeding.

You may not qualify if…

• Active infectious diseases.
• Liver or kidney dysfunction/failure.
• Uncontrolled diabetes (HbA1c ≥ 8.5).
• Active cancer treatment - such as active chemotherapy radiation therapy, or radiotherapy performed within ≤12 months from the procedure.
• Taking medications that will affect their bone healing (for example, bisphosphonates and long-term anti-inflammatory medications).
• Metabolic bone diseases that affect bone healing such as osteoporosis.
• Pregnant or lactating women (self-reported).
• Current tobacco and Marijuana smokers have 10 or more cigarettes per day, and former smokers (\> 10 cigarettes) who quit \< 10 ago (self-reported).
• Poor oral hygiene.
• Vertical loss of bone at the edentulous ridge.
• History of periodontal disease.
• The patient is pregnant or breastfeeding

Where it is running

• Unversity of Alabama at Birmingham, School of Dentistry — Birmingham, Alabama, United States (enrolling)

Full record on ClinicalTrials.gov

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