Using Tissue-based Spatial Data to Understand How Obesity-related Tumor Metabolites Fuel Prostate Cancer Progression

Recruiting now

Conditions studied: Prostate Cancer, Prostate Adenocarcinoma, Prostate Neoplasm, Prostatic Neoplasm, Obesity

In brief

Evaluate the protein expression of lactate dehydrogenase enzyme (LDHA) and MCT-1/-4 transporters, involved in lactate synthesis and transport, in prostate carcinoma tissues from severely overweight/obese (BMI \> 27.5) and non-severely overweight/normoweight (BMI \< 27.5) patients affected by prostate carcinoma. ii. Characterize the immune infiltrate in the prostate carcinoma of the aforementioned patients. iii. Assess the association between intra-tumoral lactate accumulation (using LDHA and MCT-4 protein expression levels as readouts) and alterations in the tumor immune microenvironment and/or deregulation of relevant oncogenic pathways.

Key facts

Study ID
NCT06292897
Run by
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
People needed
25
Starts
2023-03-20
Expected to finish
2027-01-15
Last updated by the study team
2024-03-05

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

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Where it is running

Full record on ClinicalTrials.gov

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