Ibuprofen Inhibits Human Sweet Taste
Completed · Not applicable
Conditions studied: Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Ibuprofen Solution in Healthy Participants, Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Naproxen Solution in Healthy Participants
In brief
The sweet taste receptor, TAS1R2-TAS1R3, is expressed both orally, where it signals sweet taste, and extraorally in the intestine and pancreas, where it may affect glucose absorption and metabolism. Recently, ibuprofen and naproxen have been identified to inhibit human T1R3 when heterologously expressed in cells. In the present study, the initial objective was to determine if ibuprofen and naproxen inhibit interactions of sugars with human sweet taste receptor under normal, physiological conditions. Ten healthy participants were asked to rate sweetness intensity for a range of sweet stimuli (sucrose, fructose, sucralose) after a prerinse of ibuprofen, naproxen or water. Both ibuprofen and naproxen inhibited sweet taste intensity in a dose-dependent manner. In association studies, ibuprofen use has been linked to preserved metabolic function, as its use is correlated with lower rates of Alzheimer's disease, diabetes and colon cancer. Here the investigators present a potential novel pathway for systemic ibuprofen to impact these metabolic diseases.
Key facts
- Study ID
- NCT06291337
- Run by
- Rutgers, The State University of New Jersey
- People needed
- 32
- Starts
- 2020-06-01
- Expected to finish
- 2023-09-30
- Last updated by the study team
- 2024-03-04
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Participant must be able to taste sugars as sweet
- Participant must be able to make ratings on a scale and follow instructions
You may not qualify if…
- Participant must not be on any medications that would preclude exposure to NSAIDS
- Participant must not be on any medications that are know to alter taste perception
Where it is running
- Food Science and Nutritional Sciences — New Brunswick, New Jersey, United States
Full record on ClinicalTrials.gov
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